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Eskalatsiya oksidativnogo stressa (OS) pri termicheskoy travme (TT) i pleyotropnyye effekty melatonina (MT) yavlyayutsya predposylkoy dlya izucheniya yego protektornykh svoystv v sostave novoy dermal'noy plenki (DP) pri ozhogakh kozhi. Tsel' raboty — otsenit' soderzhaniye markerov OS v kozhe pri eksperimental'noy TT i primenenii DP s MT. TT IIIA stepeni ploshchad'yu 3,5% modelirovali pogruzheniyem uchastka kozhi v kipyashchuyu vodu. DP ploshchad'yu 12 sm2 s MT v kontsentratsii 5 mg/g nanosili yezhednevno v techeniye 5 sut. Vychislyali ploshchad' rany i skorost' yeye epitelizatsii. V ozhogovoy rane opredelyali produkty peroksidnogo okisleniya lipidov (POL) v geptanovoy i izopropanol'noy fazakh lipidnogo ekstrakta, produkty okislitel'noy modifikatsii belkov (OMB) v spontannom i metall-zavisimom rezhimakh. Pri TT v rane na 5-ye i 10-ye sut. uvelichilos' soderzhaniye vtorichnykh i konechnykh produktov POL v geptanovoy i izopropanol'noy fazakh, summarnoye soderzhaniye produktov OMB za schet pervichnykh produktov neytral'nogo kharaktera na 5-ye sut., pervichnykh i vtorichnykh produktov neytral'nogo kharaktera na 10-ye sut. Primeneniye DP pri TT umen'shilo ploshchad' ozhoga, uvelichilo skorost' epitelizatsii rany (na 10-ye sut. po mediane s 1,90% do 6,57%; r &lt; 0,05), snizilo soderzhaniye v izopropanol'noy faze vtorichnykh i konechnykh (na 10-ye sut. po mediane s 0,007 do 0,004 ye.i.o.; r &lt; 0,05) produktov POL, snizilo summarnoye soderzhaniye produktov OMB na 5-ye sut. za schet pervichnykh produktov neytral'nogo kharaktera, na 10-ye sut. za schet pervichnykh i vtorichnykh produktov neytral'nogo kharaktera. Pri TT v usloviyakh primeneniya MT ploshchad' ozhoga assotsiirovana s soderzhaniyem v rane vtorichnykh produktov POL v geptanovoy i izopropanol'noy fazakh, konechnykh produktov POL v izopropanol'noy faze, summarnym soderzhaniyem produktov OMB, soderzhaniyem pervichnykh, vtorichnykh, osnovnogo i neytral'nogo kharaktera produktov OMB.

Lokal'nyy antioksidantnyy effekt original'noy dermal'noy plenki c melatoninom pri termicheskoy travme