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Rak predstatel'noy zhelezy — naiboleye chasto vyyavlyayemoye onkologicheskoye zabolevaniye sredi muzhchin, etomu vo mnogom sposobstvuyut rasprostraneniye skriningovykh issledovaniy i vysokaya chastota biopsiy organa. Verifikatsiya opukholey s potentsial'no boleye neblagopriyatnym prognozom techeniya yavlyayetsya pervostepennoy zadachey pri lechenii raka predstatel'noy zhelezy. Tsel'yu issledovaniya bylo opredelit' kliniko-morfologicheskiye assotsiatsii i prognosticheskuyu znachimost' ekspressii belka Nanog pri rake predstatel'noy zhelezy v razlichnykh prognosticheskikh gruppakh. Rabota vypolnena na materiale tkani predstatel'noy zhelezy, poluchennom posle operativnogo vmeshatel'stva, a takzhe obraztsakh tkani biopsii (vsego 89 sluchayev). Bylo provedeno gistologicheskoye i immunogistokhimicheskoye issledovaniye s ispol'zovaniyem antitel k belkam Ki-67 i Nanog. Korrelyatsionnyye svyazi mezhdu vyrazhennost'yu ekspressii ukazannykh markerov i prognosticheskoy gruppoy opredelyali s pomoshch'yu koeffitsiyenta Spirmena, a svyaz' s kliniko-morfologicheskimi proyavleniyami — s ispol'zovaniyem kriteriya khi-kvadrat (ch2). Obnaruzhena statisticheski znachimaya pryamaya korrelyatsionnaya svyaz' mezhdu vyrazhennost'yu ekspressii Ki-67 i Nanog i poryadkovym nomerom prognosticheskoy gruppy (rs = 0,619, p &lt; 0,001 i rs = 0,786, p &lt; 0,001 sootvetstvenno). Udalos' obnaruzhit' svyaz' mezhdu vysokoy stepen'yu ekspressii Nanog i ekstraprostaticheskim rasprostraneniyem opukholi (p = 0,041). Povyshennaya ekspressiya belka Nanog v kletkakh raka predstatel'noy zhelezy svyazana s boleye zlokachestvennymi formami adenokartsinomy i svidetel'stvuyet o neblagopriyatnom prognoze.

Immunogistokhimicheskaya ekspressiya belka Nanog v kletkakh raka predstatel'noy zhelezy razlichnykh prognosticheskikh grupp