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65 Just like chemotherapy and surgery, radiation therapy is an important cancer treatment modality. Among the problems that have been receiving a lot of attention lately are individual sensitivity of patients to radiation and the choice of adequate radiation strategy [1–3]. The efficacy of treatment can be improved by applying ultrahigh dose rate radiation, which at the same time can reduce the adverse effects of radiotherapy. However, some authors report that increased dose rates produce no biological effects, whereas others point to severe biological damage caused by radiation with ultrahigh dose rates [4–7]. Our previous in vitro study [8] has demonstrated that exposure of peripheral blood lymphocytes to photon radiation with dose rates of ~10 Gy/s entails some effects different from those of standard dose rates used in conventional radiation Т. М. Кулинич, Е. Г. Крастелев, Ю. А. Быков, В. П. Смирнов, А. М. Шишкин, А. В. Иванов, В. К. Боженко ИССЛЕДОВАНИЕ УРОВНЯ ДВУНИТЕВЫХ РАЗРЫВОВ ДНК И МЕХАНИЗМОВ КЛЕТОЧНОЙ ГИБЕЛИ ПРИ ВОЗДЕЙСТВИИ НА КЛЕТКИ РАКА ЛЕГКОГО И МЕЛАНОМЫ ФОТОННОГО ИЗЛУЧЕНИЯ СВЕРХВЫСОКОЙ МОЩНОСТИ

bulletin of russian state medical university/bulletin of rsmu

Investigation of the level of DNA double-strand breaks and mechanisms of cell death under irradiation of lung cancer and melanoma cells with ultra-high dose rate photon radiation