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World Health Organization [WHO] tahun 2015, memperkirakan angka kejadian kanker non-melanoma semakin meningkat akibat penipisan lapisan ozon. Angka kejadian kanker kulit di Indonesia mencapai 6-8%, maka kulit memerlukan perlindungan yang efektif. ZnO merupakan tabir surya dengan SPF [ Sun Protecting Factor ] 50 mampu mengurangi paparan sinar matahari pada kulit terutama UV A [320-400 nm] dan UV B [290-320 nm]. ZnO yang sukar larut dalam air menjadi kendala apabila didispersikan dalam matrix hidrogel, sehingga diformulasikan menjadi sediaan nanoemulsi dalam SNEDDS. Formula SNEDDS dibuat dengan menggunakan tween 80 sebagai surfaktan, propilen glikol sebagai ko-surfaktan, dan minyak zaitun. Optimasi formula SNEDDS menggunakan metode D-Optimal dengan bantuan software Design Expert akan didapatkan 16 formula yang dilakukan pengujian respon stabilitas fisik : nilai transmitan [%] dan nilai pH. Formula optimum SNEDDS dibandingkan dengan formula prediksi D-Optimal menggunakan analisa statistik student’s t-test [p>0,05], selanjutnya dilakukan kemampuan loading dose ZnO, uji stabilitas dipercepat, Particle Size Analysis , Zeta Potencial . Proporsi komposisi optimum tween 80, propilen glikol, dan minyak zaitun SNEDDS berdasarkan D-Optimal adalah 9,931% : 80,979% : 9,090%. Hasil respon persen transmitan sebesar 92,30% dan nilai pH 7,20 . Hasil prediksi DX transmitan 92,59% dan pH 7,37 analisa statistik one sample t-test menunjukkan tidak terdapat perbedaan antara hasil observasi dan prediksi D-Optimal . SNEDDS mampu me- loading 2,0 mg ZnO per gram SNEDDS dengan ukuran partikel 150,2 nm, polidispersi indeks 0,536 dan potensial zeta -28,5 mV. World Health Organization in 2015, estimated the case of non-melanoma cancer increasing due to depletion of the ozone layer. The case of skin cancer in Indonesia reaches 6-8%, so the skin needs effective protection. ZnO is a sunscreen with SPF [Sun Protecting Factor] value of 50 and capable of reducing sun exposure to the skin, especially UV A [320-400 nm] and UV B [290-320 nm]. ZnO is difficult to dissolve in water and obstacle when dispersed in the hydrogel matrix, so that it is formulated a nanoemulsion preparation into SNEDDS. SNEDDS consists of olive oil, tween 80 [surfactant], and propylene glycol [cosurfactant]. Optimization of the SNEDDS ZnO with the D-Optimal method using Software Design Expert will get 16 formulas which are then tested for physical stability response including transmittance values [%] and pH values. The optimum formula of SNEDDS was compared with SLD prediction using student's t-test [p> 0,05], then loading dose ZnO, Particle Size Analysis, Zeta Potencial. The proportion of optimum composition of propylene glycol, tween 80 and olive oil based on D-Optimal with physical stability parameters : percent transmittance and pH value are 9,931% : 80,979% : 9,090%. Results of transmittance percent response of 92,30% and pH value 7,20. The predicted D-Optimal value for transmittance percent of 92,59% and pH value 7,37. The result of statistical analysis of one sample t-test showed no significant difference between observation result and prediction. The SNEDDS system is capable of loading 2,0 mg of ZnO each SNEDDS with 150,2 nm particle size, 0,536 index polidispersion and zeta potential -28,5 mV.

OPTIMIZATION OF OLIVE OIL, TWEEN 80, AND PROPYLENE GLYCOL OF SELFNANOEMULSIFYING DRUG DELIVERY SYSTEM OF ZINC OXIDE BY D-OPTIMAL METHOD