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Objective. To determine the probable effect of metadoxine and guar gum on glucose homeostasis during the comorbid course of non-alcoholic steatohepatitis (NASH) with obesity and osteoarthritis (OA). Material and methods. 60 patients (30 men and 30 women) with the indicated comorbidity were examined and divided into three groups: patients of group 1 control (C) (n = 20) took Essentiale H 1 capsule 3 times a day, patients in group 2 main group 1 (M1) (n = 20) received metadoxine (Liveria IC) at 0.5 g twice daily, in 3 main group 2 (M2) (n = 20) in addition to metadoxine patients received guar gum (Guarem) 1 sachet (5 g) 2 times a day. The groups were randomized to age, sex, obesity and cytolytic syndrome activity. The control group consisted of 30 practically healthy individuals of the same age and gender. The average age of patients was (62,3 ± 5,7) years. Conclusions. The conducted analysis showed that the course of treatment with metadoxine and guar gum proved the ability to achieve stable normalization of carbohydrate metabolism over a long period of time, since guar gum together with metadoxine enhance rapid compensation of carbohydrate metabolism with impaired carbohydrate tolerance, ability to resensitize insulin receptors and eliminate insulin resistance syndrome.

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Peculiar features of glucose homeostasis in patients suffering from non-alcoholic steatohepatitis with comorbid obesity and osteoarthritis on the background of metadoxine and guar gum administration