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Impaired bone metabolism in cancer patients may be manifested by the development of osteoporosis, the appearance of pathological fractures, and the development of metastatic bone involvement. Given the need to prescribe chemotherapy for the treatment of cancer, bone regeneration is quite often the case with the use of anticancer chemotherapy. Conclusions. Cancer patients are at high risk for osteoporosis and bone fractures due to the direct effects of the tumor itself and the side effects of chemotherapy. The use of antitumor chemotherapy affects the rate of bone remodeling, in particular inhibits the function of osteoblasts, reduces their number, stimulates osteoclasts and disrupts the processes of bone mineralization. As a result, there is a decrease in bone mass, which significantly increases the risk of fractures in cancer patients during chemotherapy.

bukovinsʹkij medičnij vìsnik

Analysis of the influence of malignant new formations on the state of the bone system and study of the action of antitumor chemical drugs on bone tissue regeneration (literary review)