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50 patients with chronic pancreatitis (CP) aged from 45 to 63 including 23 patients with CP and normal body index (1st group), 27 patients with CP and obesity of the 1st degree (2nd group) were examined in the research. The diagnosis of CP exacerbation was made on the basis of anamnesis, clinical and ultrasonography findings with biochemical substantiation of hyper-fermentation syndrome. The diagnosis of obesity was made on the basis of the body mass index increasing (BMI) more than 30 kg/ m. A comparative analysis of the morphological structure of the pancreatic tissue received during autopsy of patients with CP on the background of obesity and normal body mass, died due to various reasons including complications of metabolic syndrome, has been made. In obese patients pancreas morphologically characterized by replacement of the pancreas acinar epithelial by fibrous tissue and a significant increase the number of adipocytes, which is the basis of exocrine pancreatic insufficiency. Patients with chronic pancreatitis and obesity presented considerable metabolic changes of the extracellular matrix components assuming a reliable increase of the intensity of collagen synthesis, glycoproteins content, molecular hyper-production of cellular adhesion and acute phase proteins, increased catabolism of fucoglycoproteins against a reliable decrease of seromucoids and ceruloplasmin content with antioxidant properties in the blood. Increase of proteolytic blood activity and inhibition of collagenolysis processes due to the decrease of matrix metalloproteinase-1 activity, increase of inhibitory effect power of the tissue and plasma inhibitors of proteolysis and collagenolysis were found in patients with CP on the back-

Condition component of connective tissue and systemic proteolysis in patients with chronic pancreatitis and obesity