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Background: Chronic endometritis (CE) is one of aggressive factor of infertility and reproductive losses. Objective: We aimed to assess the effectiveness of using platelet-rich plasma (PRP) treatment of chronic endometritis (CE) treatment in women with infertility (PI) and recurrent pregnancy losses (RPL). Material and methods: In this non-randomized clinical trial, women aged 2245 years with CE diagnosed by positive CD 138 between February 2017 and December 2019 were included. Were investigated 65 women 30 patients with RPL and 35 women with PI and unsuccessful attempts at IVF. PRP therapy was performed paracervical ( 6 ml) and intrauterus ( 1,5 ml) once a week for 4 -8 weeks. Control of the treatment of CE was performed by endometrial biopsy pipelines 15-20 days after the last PRP. Results: After carrying out 4 procedures of combined paracervical and intrauterine PRP, CE was cured in 70-77% of women (p <0.05); after 8 procedures 97% (p <0.01). Conclusions: Combined intrauterine and paracervical PRP therapy is an effective treatment for CE in women with PI and RPL.

Platelet-Rich Plasma in the Management of Chronic Endometritis Treatment in Women with Reproductive Health Disorders