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This paper establishes the foundational principles and practice for a unified theory of arbitrary information management by disclosing systems, devices and methods for the management of substrates or biological substrates. In this context, a substrate is any aspect of any entity that is capable of responding to or emitting stimuli irrespective of whether the stimuli actually emanate from any aspect of the entity or not. Management of substrates could be achieved through the management of stimuli that modulate or moderate or influence any aspect of the substrate as well as through the management of any stimuli emanating from the substrate. The results enable a wide range of novel applications in a variety of fields with far-reaching implications. For example, the functional organization of many regions of the brain including the superior temporal cortex which is believed to play a critical role in the hierarchical processing of human visual and auditory stimuli is poorly understood. It is not known precisely which layer within which region of the brain is responsible for which aspect of visual or auditory processing. Simultaneous non-invasive acquisition of bio-signals representing contributions from multiple layers of neuronal populations within the brain could provide new insights leading to the resolution of many of these outstanding issues and provide a deeper understanding of the underlying physiological processes.

System for Nature-inspired Signal Processing: Principles and Practice