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Objective: to observe the influence of Danhong injection on cerebral s100 (acid calcium coupling protein) protein and NSE (neuron specificenolase) of rats undergoing cardiopulmonary bypass (CPB) and then discuss cerebral protection mechanism of the medicine. Method: 24 SD rats were divided into sham operation group, CPB group and medicine intervention group at random. Each group includes 8 rats. s100 level and NSE level of the 3 groups were compared. Results: NSE level and s100 level in the cerebral tissue homogenate of CPB group rose significantly, compared with sham operation group, P<0.01. The difference was significant. NSE (P<0.01) and S100 (P<0.05) of medicine intervention group declined significantly, compared with CPB group. Conclusion: Danhong injection has certain CPB cerebral protection effect. As the most sensitive organ of human, cerebral tissue controls the whole body. Normal and stable cerebral tissue functions need relatively stable metaboilic level. Even minor injure may result in obvious structure change or function loss. In a series of bad consequences of cardiac surgery and bypass, the most common and disastrous consequence is cerebral injury[1]. To provide theoretical basis for CPB-caused cerebral injury, CPB model for rats was established, and Danhong injection was used to intervene in the model. Then, NSE level and s100 level were detected. The effect and mechanism of Danhong injection on CPB cerebral protection were discussed. 1. Material and method

Study on Relieving Cerebral Injury of CPB Rats by Danhong Injection