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Objective: to observe the influence of Danhong injection on cerebral infarction area and neuron apoptosis rate of rats undergoing cardiopulmonary bypass (CPB) and then discuss cerebral protection effect of Danhong injection. Method: 24 healthy and adult SD rats were divided into sham operation group, CPB group and medicine intervention group at random. Each group includes 8 rats. Cerebral infarction area and neuron apoptosis rate of 3 groups were compared. Results: compared with CPB group, cerebral infarction area of medicine intervention group decreased (P<0.05). Compared with sham operation group, OD value of apoptotic cells in CPB group rose significantly (P<0.01). Compared with CPB group, OD value of apoptotic cells in medicine intervention group reduced obviously (P<0.01). Bax level and Caspase-3 level of CPB group were obviously higher than that of sham operation group, while Bcl-2 was significantly lower than that of sham operation group (P<0.01). Bax level and Caspase-3 level of medicine intervention group was significantly lower than that of CPB group, while Bcl-2 was significantly higher than that of CPB group (P<0.01). Conclusion: Danhong injection can play a good cerebral protection role through lowering cerebral infarction area and neuron apoptosis rate. Medical research indicates that, continuous contact of heparinized blood with artificial surface wound tissue, and ischemia-reperfusion injury trigger pathophysiological reaction during CPB so that internal environment, tissues and organs have function disorder. This experiment aims to study the influence of Danhong injection on cerebral infarction area, neuron apoptosis rate and blood brain barrier damage caused by CPB rat ischemia so as to provide basis for cerebral protection effect of Danhong injection. 2018 7th International Conference on Medical Engineering and Biotechnology (MEDEB 2018) Published by CSP © 2018 the Authors 181 1. Material and Method

Cerebral protection Effect of Danhong Injection on CPB Rats