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Purpose. The article substantiates the strategic principles of development interaction systems in innovation processes of the region, which includes defining goals on a conceptual basis to ensure the value of interaction, clarifying the composition of subjects and objects of development regional interaction systems, implementation in certain stages.  Design/methodology/approach. The goals set in the study were solved using the following general scientific methods:  general scientific and special principles and techniques of scientific knowledge in the field of strategic management of innovative development of territories.  Semantic analysis, comparative analysis and systematization method were used to carry out the theoretical substantiation of the system of strategic goals of regional development; the method of grouping, factor analysis, the method of structural-logical modeling is used in the development of a set of operational tasks to achieve strategic goals. An abstract-logical method was used to formulate conclusions and theoretical generalization of the results of the study.  Findings. The subject of strategic management interaction in the innovation processes of the region is "innovation development", which takes into account the interests and goals of the subjects in the innovation process of the region. Strategic interaction management is carried out by defining goals on a conceptual basis to ensure the value of interaction, which involves the implementation of certain stages.  Adherence to the proposed sequence of stages will ensure the required level of interaction value in regional systems for all participants in the innovation process on a strategic basis.  The central apex of the "goal tree" is a strategic goal, in our context - ensuring the value of interaction in innovation processes. This strategic goal is deployed in tactical goals that capture large blocks of action to achieve a strategic goal, namely; block of rational use of innovation resources of the region, block of ensuring the usefulness of interaction, block of optimization of the cost of establishing interaction, block of increasing the productivity of innovation processes in the region, block of development of innovation infrastructure of the region.  Practical implications. An obligatory stage in the formation of regional cooperation systems is the coordination and harmonization of the interests of potential participants on the basis a rational compromise to achieve the goals of regional development. The specified strategic goal is developed by the authors into tactical goals, which fix large blocks of actions to achieve the strategic goal, namely the block of rational use of innovation resources of the region, the block of ensuring the usefulness of interaction in regional interaction systems, the block of optimizing regional interaction, block of development of innovation infrastructure of the region.  The need for improving regional management of the development interaction systems in innovation processes is due not only to its national importance for the development of NIS, but also the economic content - the formation of the economic base and support drivers of social and economic development of regions.  It was proved that regional government institutions should fully support the development of the economy on market principles, while assuming the main responsibility for comprehensive overall regulation and strategic planning of economic development and direct support of the innovation process.  Originality/value. For each of these blocks of strategic goals, the article substantiates a set of socio-economic tools for implementing tasks in regional interaction systems, which differ in the components of interaction systems, scope, nature of direction, duration, complexity of use, level of consistency, purposes of use, source of funding, direction raising funds.  Summarizing the substantiation of strategic goals for interaction systems development in innovation processes of the region, it is necessary to emphasize harmonization and coordination of goals of interaction system formation with goals of innovative development of the region and individual goals for potential participants of interaction systems. After all, the development of interaction systems takes place through the maximum involvement of market stakeholders in cooperation and ensuring the value of their coordinated joint work on innovative projects and programs.

STRATEGIC GUIDELINES OF REGIONAL MANAGEMENT DEVELOPMENT OF SYSTEMS INTERACTION IN INNOVATIVE PROCESSES OF THE REGION