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Objectives: The present study was conducted to assess Single Nucleotide Polymorphism (SNP) of adiponectin gene (ADIPOQ rs2241766) variant SNP + 45 T > G with reference to thyroid status in the three study groups, namely non-obese, overweight and obese type 2 diabetics. Methods: 150 Type 2 diabetics of both genders who had visited the tertiary health care clinics during the stipulated study period were included. Based on BMI (18.50 to 24.99, 25 to 29.99 and ≥ 30 respectively), they were segregated into nonobese, overweight and obese (n = 28, n = 76 and n = 46 respectively). The cardio-metabolic risk factors were assessed through parameters including anthropometric and routine biochemical measures, besides glycemic status and insulin resistance. The divalent cations (Zn2+ and Mg2+) were quantitated in serum. Serum free T4, T3 and TSH were estimated to evaluate thyroid status. PCRRFLP was carried out to decipher the gene polymorphism of ADIPOQ (rs2241766) T > G of exon 2 in Adiponectin gene with particular reference to the implications in personalised medicine. Results: A positive association was found between SNP + 45 T > G in exon 2 and T2DM in the study population. Data on genotyping among non-obese vs. overweight depicts association with LDL in TT (Homozygous) p = 0.0491, while in TG (Heterozygous) phenotype, a strong association was perceived with Insulin resistance (p = 0.006). Associations concerning TSH in TT p = 0.0339; Mg, p = 0.0145 and p = 0.0138 in TT & TG respectively in obese vs. overweight and T4 in TT with p = 0.0491 were observed in non-obese vs. obese T2DM. Conclusion: SNP + 45 T > G gene polymorphism in adiponectin gene may be a cardinal feature in insulin resistance observed in type 2 diabetes mellitus for consideration, based on BMI. Also, the wild type (TT) depicted good association with TSH, T4 and LDL in obese vs. overweight, non-obese vs. obese and non-obese vs. overweight type 2 diabetics respectively to stimulate interest in personalised medicine.

journal of obesity and weight-loss medication

Gene Polymorphism of Adiponectin SNP + 45 with Reference to Thyroid Status - A Comparative Study among Non-Obese, Overweight and Obese Type 2 Diabetics