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Purpose: Patients with end-stage renal disease (ESRD) under dialysis showed a higher prevalence of depression, which is independently associated with non-adherence, hospitalization and mortality. We aimed to evaluate the prevalence of depression and associated variables, among ESRD late-life patients under onlinehaemodiafiltration (OL-HDF). Methods: An observational cross-sectional study that included 114 late-life patients under OL-HDF was conducted. Depression status was evaluated using the geriatric depression scale (GDS). Social support was also evaluated, as well as sociodemographic, comorbidities and haematological data, iron status, dialysis adequacy and nutritional markers. Results: Our results showed that 43% (n = 49) of our dialysis patients showed a GDS score lower than 5, 28.1% (n = 32) showed a GDS score between 5 and 8, and 28.9% (n = 33) showed a score of 9 or more. When the three groups of patients were compared, we found significant differences in age, creatinine, substitution fluid volume, relative fat, fat tissue index (FTI), lean tissue index (LTI), lean tissue mass (LTM) and social support scores. Significant positive correlation was found between the GDS score and KTv, FTI and relative fat; and a negative correlation was found with social support score, creatinine, LTM and LTI. Conclusions: Our results showed a high depression rate in dialysislate-life patients, which is associated with low social support and decreased muscular mass and creatinine serum levels. It will be important to consider social support as pivotal in non-pharmacological interventions to reduce depression in order to enhance adherence to medical plans, reduce health resource utilization and costs, and improve survival rates.

journal of clinical nephrology and renal care

Depression in Late-Life patients with End-Stage Renal Disease under Online-Haemodiafiltration is Associated with Low Social Support, Muscular Mass and Creatinine Serum Levels