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Hepatitis B infection continues to be a serious global health problem with about 2 billion people infected worldwide, many of these in sub-Saharan Africa. Methods: Records of Hepatitis B surface and envelope antigen test results in adults attending the outpatient units and/ or admitted in Federal Teaching Hospital, Gombe between May 2000 and May 2015 were retrieved and analyzed. Results: Hepatitis B surface antigen was tested for in 22,862 adults and children; 20375 (89.1%) were adults and 2487 (10.9%) were children. Adult Males were 11420 (56.0%) and females 8955 (44.0%). 4796 (23.5%) of tested adults were 19-25years; 11634 (57.1%) 26-45 years; 2074 (10.2%) 46-55 years; 5.5% (1112) and 759 (5.4%) > 65years. 4015/20375 (19.7%) were positive for Hepatitis B surface antigen. 2883/4015 (71.8%) males and 1132 (28.2%) females were Hepatitis B positive. 887/4015 (18.5%) between 19-25 years, 2533 (21.8%) among 26-45 year old individuals; 397 (19.1%); 136 (12.2%) and 62 (8.2%) of 46-55 year old, 56-65 year old and > 65year old individuals screened were Hepatitis B positive. 1361/4015 (34.0%) of HBsAg seropositive individuals were tested for HBe antigen. Males were 954 (69.4%) and females 407 (30.6%). HB e antigen was positive in 321/1361 (23.6%) of HBsAg carriers; 238 (74.1%) males and 83 (25.9%) females. 133 (41.4%); 165 (51.4%); 17 (5.3%); 4 (1.2%) and 2 (0.6) of HB e sero-positivity were among age groups 19-25, 26-45, 46-55, 56-65 and > 65 year old individuals respectively. 95/226 (42.0%); 126/600 (21.0%); 13/100 (13.0%); 3/23 (13.0%) and 1/5 (20.0%) of males aged 1925; 26-45; 46-55; 56-65; and > 65 years had HB e antigen respectively. Among females 38/116 (44.2%) aged 19-25; 39/241 (16.2%) 26-45; 4/44 (9.1%) 46-55; 1/5 (20.0%) 5665 and 1/1 (100%) had HBe antigen. Conclusion: Prevalence of Hepatitis B surface antigen is high in our facility and overall prevalence of Hepatitis B e antigen of 23% is an under estimation as only a third of Hepatitis B surface antigen carriers were tested. Implication for treatment is significant. OrIgInAl ArtIClE

Hepatitis B envelope antigen in adult carriers of Chronic Hepatitis B surface antigen in a Tertiary Health Facility in North East Nigeria: 2000 - 2015