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The aim of our study was to describe the socio-demographic, clinical, therapeutic and evolutionary characteristics of patients admitted to tuberculosis re-treatment and managed at the The Infectious and Tropical Diseases Department (SMIT) screening and tuberculosis treatment center (TTC), to determine the factors associated with unfavourable outcome Methodology: This is a descriptive and analytical retrospective cross sectional study covering all tuberculosis re-treatment cases monitored in the service of infectious and tropical diseases in Fann from 1 January 2011 to 31 December 2016. The Epi-Info software version 7 CDC and SAS (version 9.3, Cary, NC, USA) were used for data entry and analysis. Results: We collected 83 patients as re-treatment tuberculosis cases during the study period, for an annual average of 14 cases. The average age of the patients was 42.2 years ± 13.6 years, with extremes of 16 and 77 years. There was a male predominance (66.3%) with a sex ratio of 1.96. The majority (95.2%) of our patients came from the Dakar region, 42.2% of them from the suburban area. More than two thirds (77.1%) of our patients were hospitalized. Clinically, the average weight at initiation of tuberculosis treatment was 48.1 kg ± 9.9 kg. The isolated pulmonary form accounted for 63%, followed by the multifocal form 23%. HIV seroprevalence was 73.6% and 92.9% of these patients were on cotrimoxazole chemoprophylaxis and 60.7% on ARV treatment. Relapses (61.4%) and treatment after default (36.1%) constituted the majority of the re-treatment circumstances. The unfavourable outcome was related to provenance in suburban areas and outside Dakar (AOR = 17.5; 95% CI: 3.61 85.4). Conclusion: Compliance and monitoring of retreatment cases is important to avoid TB drug resistance. It is necessary to improve the referral and counter-referral system as well as communication between the different tuberculosis treatment centers.

journal of infectious diseases and epidemiology

Tuberculosis Re-Treatment Cases and Factors Associated with Unfavourable Outcome at the Fann University Hospital of Dakar, Senegal between 2011 and 2016: A Follow-Up Study