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Background: The correlations between protective and risk factors in Brazilian families with substance misuse problems were investigated in this study. Methods: A case-control study was conducted with a convenience sample; the participants were paired by sex and age. Three hundred five families with children and adolescents (4-18 years of age) were evaluated; 60% (n=183) were in the study group, and 40% (n=122) were in the control group. In the study group, 73% (n=133) of the families had fathers with drinking problems and 27% (n=50) had fathers with illicit poly-drug addiction. Results: Parents with illicit drug dependence problems showed a greater number of clinical aspects to their children’s psychological development than parents with alcohol addiction, as the proportion of this group was (CBCL: withdrawn (59%); somatic complaints (24.5%); social problems (29%); thought problems (12%); delinquent behavior (24,5%); externalizing (55%); and total problems (55%)). However, both substances are equally harmful and can trigger mental health risks in children, especially younger children. Regarding the risk of mental health problems, the findings indicate that 39% (n=115) of the children demonstrated externalizing problems and 33% (n=97) demonstrated internalizing

Logistic Regression to Assess Risk Factors in Offspring from Brazilian Families with Alcohol and Drug Problems