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Objectives: Glioma, a malignant intra-axial brain tumor, can release glutamate that facilitates tumor expansion, stimulates tumor-cell proliferation and motility and promotes epileptic activity. Glutamate acid is the major excitatory neurotransmitter in the mammalian Central Nervous System. We explore correlations of glutamate concentrations in blood and cerebrospinal fluid in patients with glioma in comparison to patients with meningioma which is the most common benign cerebral tumor. Experimental design: Samples from 16 patients with glioma and 13 patients with meningioma were analyzed. Glutamate levels in blood and cerebrospinal fluid were measured by HPLC method. Principal observations: Mean value ± SD of Glu concentration

Glutamate Concentrations in Plasma and CSF in Patients with Glioma and Meningioma