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Improvement of neonatal intensive care in the modern era has greatly changed the demographic image with evolving new generation of extreme preterm survivors. And indeed, evolving new co-morbidities that influence the short and long-term outcomes of these infants. Periventricular-Intraventricular hemorrhage (PVH-IVH) is a significant health problem affecting the brain structures in a critical stage of development in preterm infants. Although the incidence has declined since the 80’s of the last century, PVH-IVH continued to be a costly co-morbidity in this subset of infants. Life-long neurological sequelae especially cerebral palsy, seizures, coordination disorders, and developmental delay are major concern to health care givers and represent significant economic and social burden to the family. This review offers an update on the pathogenesis, diagnostic neuroimaging modalities, and the long-term neurodevelopmental outcomes of mild grades PVH-IVH in preterm survivors.

Impact of Low Grade Periventricular-Intraventricular Hemorrhage on Neurodevelopmental Outcome of Preterm Infants