English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: The A(H1N1)pdm09 virus is a major pathogen causing acute respiratory diseases (ARD) in children worldwide, leading to high rates of ambulatory consultations and hospitalizations. The seasonal influenza of 2012/2013 in Germany was unusually severe, leading to higher numbers of hospitalization rates as compared with previous seasons. This trend was even notable in our tertiary care Children’s Hospital at the University of Bonn, Germany. Patients and Methods: Data of 74 hospitalized children (≤ 18 years) from the pandemic season in 2009/10 and the post pandemic season 2012/13 with ARD and A(H1N1)pdm09 virus infection were analyzed. A retrospective patient’s chart analysis was performed. Results: During the pandemic more children with detection of A(H1N1)pdm09 virus need to be hospitalized (48 vs. 65%). Children were younger in the post-pandemic season 2012/13 than 2009/10 (6.5 vs. 2.1 years, p < 0.01) and the hospital length of stay was longer (5.1 vs. 10.8 days, p < 0.01). Proportionally more children in 2012/13 presented with pneumonia (22 vs. 47%, p = 0.05), suffered under an airway obstruction (25 vs. 73%, p < 0.01) or tachypnea (7 vs. 33%, p < 0.01). Needs for oxygen therapy (12 vs. 47%, p < 0.01) and intravenous fluid replacement (24 vs. 73%, p < 0.001) were augmented. Conclusion: The clinical course of German children with seasonal A(H1N1)pdm09 virus infections in 2012/13 appeared to be more severe than during the pandemic 2009/10. Influencing factors for this difference are probably multifactorial. Physicians need to focus especially on infants and preschool children, because these patients are at higher risk for severe clinical outcome and prolonged hospital stay.

A Clinical Comparison of Hospitalized Pediatric Patients with Influenza A(H1N1)Pdm09 Virus Infection of the Years 2009/10 and 2012/13