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Background: Periungual warts (PW), also known as verruca vulgaris, are caused by the human papilloma virus and appear as skin lesions located around the nailfold but can also affect the nail plate. Unfortunately, some of the therapies mentioned are destructive by nature and can also damage the nail matrix, hyponychium or underlying bone. Case description: Here we describe a patient resistant to a range of standard treatments. His clinical condition dramatically improved after use of isolated transfer factors (TF). Conclusion: As shown in this case, TF could be a possible effective alternative to treat therapy resistant PW and we hope this report will lead to further investigation, including controlled trials with TF in this patient group.

Effect of Sublingual Isolated Transfer Factors in a Case of Therapy Resistant Periungual Warts