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Objective: To clarify a possible role of prostatic trace elements in an etiology of age-dependent gland diseases such as benign prostatic hyperplasia and prostate cancer. Methods: The variation with age of the 54 trace elements concentration in prostatic parenchyma and the relationship of these trace elements with basic histological structures of nonhyperplastic prostate glands of 65 subjects aged 21–87 years was investigated by an instrumental neutron activation analysis combined with inductively coupled plasma atomic emission spectrometry and a quantitative morphometric analysis. Results: A significant trend for increase with age in Bi, Cd, Co, Fe, Hg, Sc, Sn, and Zn concentration as well as for increase with age in relative volume of stroma and decrease in relative volume of epithelium was found. It was demonstrated that the glandular lumen and, therefore, prostatic fluid is a main pool of Zn accumulation in the normal human prostate, for the age range 21 to 40 years. For age above 40 the redistribution of trace elements between prostatic cells and fluid begins. In this period of life stroma is the main pool of Al, Br, Cd, and Th accumulation in the normal human prostate. Conclusions: For ages above 40 years conclusive evidence of a disturbance in prostatic trace element concentrations and their histological distribution was shown.

Age-Related Changes in Concentration and Histological Distribution of 54 Trace Elements in Nonhyperplastic Prostate of Adults