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Objective: Fatigue has been intensively studied in patients with systemic lupus erythematosus (SLE). However, previous studies have mostly included patients with long-term disease who have been treated with corticosteroids. We investigated fatigue in corticosteroid-naive patients with early-stage SLE. Methods: Forty-three SLE inpatients without neuropsychiatric SLE manifestations and 30 healthy control subjects with similar demographic characteristics participated in this study. The Profile of Mood States (POMS) was used to assess fatigue, depression and anxiety. Results of clinical, laboratory, and neurological tests were compared and their relationship with fatigue was assessed. Results: The prevalence of fatigue did not differ between patients (n = 8, 19%) and controls (n = 6, 20%; p = 0.556), and the severity of fatigue also did not differ between groups (p = 0.590). Using multiple logistic regression analysis, we identified POMS-anxiety (OR, 1.14; 95% CI, 1.019 1.273, p = 0.022) as an independent risk factor for fatigue in these patients. There were no relationships between fatigue, disease activity, and concentrations of inflammatory markers. Conclusion: Our results indicate that fatigue does not occur more frequently in corticosteroid-naive patients with early-stage SLE than in the normal population, and that fatigue may be related to anxiety.

Fatigue in Patients with Early-Stage Systemic Lupus Erythematosus Before Receiving Corticosteroid Therapy: A Prospective Cross-Sectional Study