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Background: The effects of creatine supplementation in older people are dubious. Aim: To assess the effects of creatine supplementation in older women subjected to resistance training. Material and Methods: Older women aged between 60 and 75 years without chronic debilitating diseases, living in the community were invited to participate. All were subjected to supervised resistance training using elastic bands, three times per week during 12 weeks and were randomized to receive, in a double blind fashion, 5 g/day of creatine monohydrate or maltodextrin, during the same period. At baseline and the end of the intervention period, blood pressure was measured, body composition was evaluated by double energy X-ray absorptiometry (DEXA), quadriceps torque was assessed in a quadriceps table, timed up and go (TUG) and the 12 minutes’ walk tests were carried out. Compliance with the supplement and training sessions was evaluated periodically recording the attendance to training sessions, evaluating subjective effort during exercise sessions using the OMNI-Resistance Exercise Scale and counting the leftover sachets of creatine or placebo. Results: Fifty participants were randomized and 39 (17 in the placebo and 22 in the creatine group), completed the intervention. Among the latter, compliance with training and the supplement was over 80%. After the intervention period, total and appendicular fat free mass, right quadriceps torque and twelve minutes test increased significantly in all participants. Significant reductions in diastolic blood pressure and hip circumference were also observed. No significant differences were observed in the change of these parameters between participants receiving the active supplement or placebo. Conclusions: Creatine supplementation had no effect on muscle mass or function in these women.

Controlled Trial on the Effects of Creatine Supplementation on Muscle Mass and Function among Older Women Subjected to Resistance Training