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The gastrointestinal epithelium is one of the tissues with highest self-renewing rates under steady-state conditions, and it thereby constitutes an excellent model to better understand how tissues maintain homeostasis. In the past decade, intense research in this field has allowed identifying stem cells responsible for this task and has contributed to uncover the main molecular mechanisms associated with self-renewal and differentiation properties of these cells. One of the future challenges is to fully dissect signaling processes associated with adult regeneration to design new therapies in patients with gastro-intestinal disorders. Here, we review recent advances regarding the identity of cells involved in adult homeostasis and regeneration in the small intestine and stomach. The recent characterization of the developmental epithelial progenitors involved in tissue morphogenesis has provided evidences that epithelial remodeling involved in fetal and adult regenerating tissues share common molecular processes.

Stem Cells in Adult Homeostasis, Regeneration and Tissue Development of the Digestive Tract Epithelium