English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Data on the safety of a cluster regimen to start a subcutaneous immunotherapy (SCIT) with house dust mite (HDM) extract in pediatric patients are scarce. This study investigates the rate of adverse events (AEs) and the applicability of a cluster regimen for HDM SCIT in pediatric patients, and identifies possible risk factors for the development of AEs. A total of 147 injections with a depot extract (D. pteronyssinus / D. farinae, 50% each) were applied to 21 HDM-sensitized pediatric patients (age 5-18 years) with allergic asthma and/or allergic rhinitis within 2 weeks. All patients completed the cluster regimen with the full cummulative dose. Systemic adverse events (AEs) were mild to moderate (rhinitis, nausea or mild asthma), and occurred after 5 injections (3.4%) in three different patients (14.3%). Local AEs occurred in 14 patients (66.7%); 11 patients had minor local AEs and only 3 patients had major local AEs of a diameter ≥ 5 cm. All AEs developed within 60 minutes after the last injection. Patients with local AEs had higher total IgE serum levels than patients without AEs (p = 0.02). In conclusion, the cluster regimen for induction of HDM SCIT is a safe and well tolerated procedure in children.

Fast Updosing of Subcutaneous House Dust Mite Immunotherapy is Well Tolerated by Pediatric Patients