English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective: To explore a new therapy for patients with certain subtypes of infective endocarditis. Methods: The experience of transcatheter closure combined with antibiotic therapies at our cardiovascular center was retrospectively analyzed in 5 cases of infective endocarditis with congenital heart disease. Transcatheter closure was performed at least 7 to 10 days after the patient’s body temperature had recovered normal following effective antibiotic therapies, and after cardiac vegetations were not detected by echocardiography. Results: Patients’ age ranged from 8 to 24 years, with a median age of 14.4 years. All 5 patients had an insidious onset of mild to moderate fever and malaise with mild anemia. Blood culture of bacteria was positive for Gram-positive cocci (staphylococcus and streptococcus) in 4 patients. All 5 patients had confirmed underlying heart disease: 4 patients with patent ductus arteriosus (PDA) and 1 with peri-membranous ventricular septal defect (VSD). Vegetations were detected in tunica intima of the main pulmonary arteries of the two patients with PDA, and on the ventricular aspect of tricuspid valve (3 mm × 4 mm in size) of another patient with VSD. All defects were successfully occluded without causing any complications. During the follow-up period (19.6 ± 14.4 months), no residual shunt or no device embolization or recurrence of cardiac vegetation was observed in any of the patients. Conclusions: Transcatheter interventional therapy may be a useful method for certain patients with infective endocarditis and congenital heart disease following intravenous application of effective antibiotics.

Transcatheter Closure Combined with Antibiotic Therapies for Patients with Infective Endocarditis and Congenital Heart Disease