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Background: To evaluate retinal function and fixation stability in major depressive disorder (MDD) and the influence of antidepressant therapy, using the MP-1 microperimeter. Methods: 25 patients with MDD (57 ± 13.73 years) and 25 healthy subjects (HS) (56.41 ± 15.73 years) were enrolled. According to the Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV), single (296.2) or recurrent episode (296.3) of MDD was included. Retinal sensitivity, fixation stability, and bivariate contour ellipse area (BCEA) were obtained using MP-1. Then patients were divided according to antidepressant therapy: SSRI/SNRI associated with atypical antipsychotic (group A) and SSRI/SNRI monotherapy (group B) and pharmacological washout (group C). Differences between groups were estimated using the Kruskal-Wallis test with post hoc Mann-Whitney analysis. Spearman’s rank correlation was used for comparisons. Results: Mean retinal sensitivity was significantly reduced in the MDD group than HS (P= 0.02). Six (24%) eyes had a relatively unstable fixation, and mean BCEA was larger than control group (P =0.04). The Kruskal-Wallis analysis of variance showed significant differences in log BCEA between groups (P=0.01), but no differences in mean retinal sensitivity between groups (P=0.09). Conclusion: MDD patients showed impairment in retinal sensitivity and fixation stability respect to the HS. Despite these findings, the impairment of fixation stability seems to be related to antidepressant therapy.

Eye-Fixation Behavior in Major Depressive Disorder and the Influence of Pharmacological Therapy: A Microperimetric Study