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Background: Pleural mesothelioma is aggressive, surgery is the principal treatment. Mesothelioma usually diagnosed in an advanced stage. The present study was conducted to study the circulating MiR-497-5p as a possible non-invasive molecular marker for the diagnosis of mesothelioma and its role in follow-up and prognosis. Methods: MiR-497-5p was evaluated in Mesothelioma tissues and the plasma of patients and the plasma of healthy controls. MiR-497-5p was assessed in the plasma of patients before and after surgical excision of mesothelioma. Results: MiR-497-5p was downregulated in tumor tissues compared to normal tissues; it was also downregulated in the plasma of patients compared to the healthy controls. MiR-497-5p levels in the tissues and plasma were comparable. The plasma levels of MiR-497-5p were elevated in the patients after tumor excision. Downregulation was associated with adverse prognostic features. Conclusions: MiR-497-5p acts as a tumor suppressor in mesothelioma. The circulating MiR-497-5p can be used as a possible non-invasive molecular marker for diagnosis and prognosis in mesothelioma patients.

Circulating Mir-497-5p as a Potential Non-Invasive Molecular Marker for Diagnosis and Prognosis in Mesothelioma