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Background: The histopathology and molecular genetics of endometrial cancer have been extensively studied, and they continue to receive attention and new interpretations. However, few studies have evaluated patients’ personal and clinical characteristics, or family history, with respect to the tumors’ molecular changes. The aim of our study was to evaluate the personal and familial information of patients with respect to several molecular genetic findings of their endometrial cancers. Methods: 105 uterine carcinomas were evaluated for mutations in the genes Ki-Ras, BRAF, GNAS, and PTEN. Loss of heterozygosity of APC and PTEN was assessed. Tumors were evaluated for microsatellite instability, and methylation was assessed in those tumors with microsatellite instability. An extensive history was obtained from the patients including family history, medical history, and personal characteristics of cigarette, coffee, and medication use. Results: Age at diagnosis was significantly related to the presence of methylation. BMI under 30 was significantly associated with PTEN mutation. We did not find any significant correlation between the presence of diabetes, hypertension, coffee consumption or use of nonsteroidal anti-inflammatory drugs or cigarettes with the various genetic changes. Estrogen use was associated with microsatellite instability. Vitamin use was more frequent among women with tumors demonstrating PTEN LOH. No correlation was found between any of the genetic changes and whether the patient had a first-degree or second degree relative with uterine cancer. Conclusions: Although certain germ line genetic changes, as well as unopposed estrogenic effect and obesity may predispose a woman to the development of uterine cancer, the specific molecular changes within the tumor may develop from multiple other exogenous influences, most of which remain undefined. The challenge for the future is to combine large clinical cohorts that have detailed clinical patient information with molecular information of their uterine cancers in an effort to define these influences.

Women's Personal and Life-Style Characteristics as Related to Molecular Genetic Changes within Their Uterine Cancers