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Since the worldwide demographic ageing, prevalence of the most common cause of dementia in the elderly, Alzheimer’s disease (AD), will increase dramatically. Although it has been intensively researched for many years, there are still limited treatments for AD. Currently approved pharmacotherapy is generally considered have symptom-relieving rather than disease processing modifying effects. Meanwhile, there are efficacy limits of such medicines, for example, donepezil efficacy starts to decline from the peak in 3 month and gradually drop below the baseline in 9 months in patients. Thus, how to improve cognitive function beyond this limitation is a worldwide challenge. With our clinical experience, we propose a combinatory therapy of ChEI and herbal medicines for it. Here is a report of a 65-year-old man with moderate probable AD with head trauma. He has been improved slowly by the combinatory therapy at cognitive function and global status nearly two years, from 18 scores on MMSE at his first visit to 21 scores at final visit.

A Combinatory Therapy Continuously Improves Memory in a Case of Probable Alzheimer's Disease with Head Trauma for Nearly Two Years