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A 38-year-old female with a 7-year history of recurrent high-grade astrocytoma was admitted to our institution presenting with progressive signs of increased intracranial pressure. MRI showed widespread tumor recurrence with diffuse infiltration of the ventricular walls, basal cisterns and concomitant hydrocephalus. After careful consideration a palliative endoscopic third ventriculostomy was performed. After surgery the patient’s condition improved significantly. Thus far she had only undergone radiation, therefore now chemotherapy was initiated. After 4 courses of Temozolomide a follow-up MRI showed no pathologic contrast enhancement. Six months later the patient is still alive in good clinical condition (KPS 90%).

international journal of neurology and neurotherapy

In Dubio Pro Therapia: Unexpected Recovery after Palliative Endoscopic Third Ventriculostomy and Temozolomide Chemotherapy in a Patient with Progressive Glioblastoma multiforme