English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Osteoclast-like giant cells have been reported in variety of different tumor types including breast carcinoma, pancreatic carcinoma, ovary tumor, uterine leiomyosarcoma, hepatocellular carcinoma, renal cell carcinoma. To the best of our knowledge, there are only two previous case reports in the literature showing endometrial stromal sarcoma with osteoclast-like giant cells. Endometrial stromal sarcoma is a rare uterine malignant neoplasm and includes low grade and high grade types. Here, we report a case of high grade endometrial stromal sarcoma with osteoclast-like giant cells. A 54-year-old female presented with a recent history of postmenopausal bleeding, a subsequent computed tomography scan revealed a large uterine/pelvic mass. Histologic examination revealed a malignant spindle cell neoplasm with tumor necrosis and some areas with clusters of osteoclast-like giant cells interspersed in the tumor. The neoplastic spindle cells were positive for CD10 and cyclin D1, negative for desmin, caldesmon and SMA. The osteoclast-like giant cells were also diffusely positive for cyclin D1.

High Grade Endometrial Stromal Sarcoma with Osteoclast-like Giant Cells: A Unique Subtype of a Rare Tumor