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Segregation of various ions on the either side of the cell membrane is the key factor responsible for the resting membrane potential (RMP). Presence of transmembrane voltage-gated ion channels is the hallmark of excitable tissues which participates in generation of impulses — Action potentials (APs). Self generation of APs (Automaticity) is seen in pace maker cells / pace maker tissue distributed in various parts of the body and act as rhythm generators. These rhythm generators are either local/regional or central. The best examples for local rhythm generators being sino-atrial node (SAN) present in the heart and interstitial cells of Cajal in gastrointestinal tract where as central rhythm generators (also known as central pattern generators or central program generators) are a network of neurons located in central nervous system (CNS) which act as a driving force for the activity of different organs and systems.

Intracellular divalent ion oscillations: Is this the key phenomenon in rhythm generators?