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Gums and mucilage are mainly explored for its various applications in dosage form development. Salvia hispanica (Lamiaceae) i.e. Chia seed mucilage mainly composed of xylose, glucose and methyl glucuronic acid that forms a branched polysaccharide of high molecular weight. The present study strives to investigate the disintegration ability of Salvia hispanica mucilage in the formulation of fast dissolving tablets of selected model drug indomethacin. Indomethacin belonging to the category of NSAIDs and is used as a therapeutic agent for relieving pain, inflammation and joint stiffness. Salvia hispanica mucilage was isolated and characterized by physicochemical parameters. Indomethacin tablets (F1-F5) were formulated by direct compression method using S. hispanica mucilage powder in varying concentration range of 2%, 4%, 6%, 8% and 10% respectively. Crospovidone (6%) was used as synthetic disintegrating agent for comparison. Micro crystalline cellulose was used as tablet diluent, mannitol, talc and magnesium stearate were used to enhance mouth feel and as lubricants respectively. All the formulations were evaluated for their pre and post compression parameters like tablet hardness, thickness, % friability, wetting time, drug content, disintegration time which was found to be in permissible limits. Drug excipient compatibility study was carried out using FTIR technique. The formulation F3 containing 6% of Salvia hispanica mucilage exhibit maximum drug release of 98.5% in 30 minutes, F4 and F5 formulations containing 8% and 10% of Salvia hispanica mucilage showed 82.4% and 80.5% drug release in 30 minutes. Results of in vitro drug released kinetic study indicated that the optimized formulation F3 followed Korsmeyer Peppas model with R2 value of 0.9793. Stability studies performed on F3 formulation indicated that the prepared tablets remain stable for the period of 90 days and showed no change *Corresponding Author: Reecha Madaan, e-mail: reecha.madan@chitkara.edu.in Reecha Madaan ORCID Number: 0000-0002-4362-0272 Rajni Bala ORCID Number: 0000-0002-6960-3403 Simran Kaur Zandu ORCID Number: 0000-0002-6764-2329 Inderbir Singh ORCID Number: 0000-0002-1860-4246 (Received 09 September 2019, accepted 05 November 2019)

Formulation and characterization of fast dissolving tablets using salvia hispanica (chia seed) mucilage as superdisintegrant