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Silybum marianum (L.) Gaertn (synonym Carduus marianus L.) is known as milk thistle. It belongs to Asteraceae family. It originates from the Mediterranean area. However, it has spread to other countries in Europe, Asia, Australia and both Americas1. The primary content of S. marianum is the presence of a group of flavonolignans known as silymarin in the pericarp and seed coat 2. The rate of flavonolignans is usually between 1.5% and 3.5% of the fruit weight1. Silymarin consists of silybin, isosilybin, silydianin, silychristin, isosilychrystin and isosilybinin1.3. Since among flavonolignan compounds silybin has detoxificationing ABSTRACT

Determination amount of silymarin and pharmaceutical products from milk thistle waste obtained from cold press