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Background: Tinea Pedis is one of the most common dermatophytosis and sometimes presents with moccasin or hyperkeratotic Tinea Pedis. Some topical antifungals are effective; however, long duration of therapy is required, which often reduce the treatment compliance of patients. Methods: To seek insights on short period therapy in hyperkeratotic Tinea Pedis, we conducted a multicentre, retrospective analysis of data collected from 36 dermatology clinics to study effectiveness and safety of Luliconazole 1% and Salicylic acid (SA) 3% as FDC cream applied for 2 weeks. Results: A data of 109 patients’ were included in this analysis. All patients have received some of the topicals and switched to FDC. Fifty eight patients received FDC as once a day (Group 1) and 51 patients as twice a day (Group 2). The clinical improvement rate (percentage of ‘marked improvement’ plus `moderate improvement’) was >60% after 2 weeks of treatment in both the groups. Patients in both the groups tolerated therapy very well. In group I, 15 patients (25.8%) experienced AE and in group II, 32 patients (62.7%) reported AE. Majority of AE were mild in nature and none of the patients discontinued treatment in entire treatment duration. But significant difference was noted between two groups in terms number of AE (p<0.05). Conclusion: Hyperkeratotic Tinea Pedis is more recalcitrant to treatment due to thick scales leading to ineffectiveness of topical antifungals. The short combination therapy with luliconazole and salicylic acid has been found to be effective and safe. Though it is one of the valuable options for hyperkeratotic Tinea Pedis, but it should be prescribed as once a day only to minimize AE.

Usefulness of Luliconazole 1% and Salicylic Acid 3% as FDC Cream in the Treatment of Hyperkeratotic Tinea Pedis