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The asthma-chronic obstructive pulmonary disease overlap (ACO) has recently attracted attention and triggered debate as evidenced by the proliferation of articles, reviews and editorials dedicated to this topic. Most of this debate is based on the lack of a consistent definition and the scarce knowledge of its underlying mechanisms. Spain has been very active in pursuing a better understanding of this topic and in developing a clearer definition to help clinicians identify and treat this condition correctly. This paper reviews the current evidence supporting its existence and the latest findings related to its mechanisms and it points out the limitations of using the classic labels to classify chronic airways diseases. (BRN Rev. 2018;4(4):245-57) Corresponding author: Borja G. Cosío, borja.cosio@ssib.es

Asthma-Chronic Obstructive Pulmonary Disease Overlap in Spain: Anything Special?