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After 20 years of service to The Einstein Quarterly Journal of Biology and Medicine (EQ), Dr. Sam Seifter is stepping down from his position as Chairman of the editorial board. His insight, advice, and energy were essential to the emergence of the EQ from its conception to the high-caliber student-run journal it is today. This issue is the first published without Dr. Seifter at the helm. This article is an acknowledgement and an appreciation of his enormous contributions to the EQ and to the Albert Einstein College of Medicine (AECOM) at large.