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This research has the focus on developing a paper-based device capable of sequentially flowing three separate fluids. Different assembly methods are investigated and compared to develop a more streamlined approach for the prototyping and testing of biological reagents. A faster method of fabrication is developed followed by an investigation of the potentials to detect the presence of Inter α Inhibitor Protein (a biomarker associated with sepsis). This is primarily achieved by applying the techniques of an Enzyme Linked Immunosorbent Assay (ELISA) onto a paper based platform. The research presented shows the steady progression toward and optimization of a lateral flow device capable of achieving the above and eventually presenting the capability of a competitive ELISA to detect IαIP. This platform allows for the possibility to generate results within a fraction of an hour and furthermore with smaller fluid volumes as compared to current bench top tests, such as ELISA which is typically conducted in 96 well plates.

DEVELOPMENT OF A PAPER BASED LATERAL FLOW DEVICE FOR THE DETECTION OF IαIP VIA COMPETITIVE ELISA