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Background and Objectives: Diabetes mellitus and Non-Alcoholic Fatty Liver Disease (NAFLD) are two highly prevalent and related diseases. Research have shown that they can affect the expression and activity of enzymes integral in the clearance of xenobiotics. Such enzymes include the Cytochrome P-450 isoforms 2C8 and 2C9. Our objective is to study the effect of these diseases on CYP2C8 and CYP2C9 using in vitro tools.

EXPRESSION AND ACTIVITY OF CYP2C8 AND 2C9 IN DIABETES MELLITUS AND NONALCOHOLIC FATTY LIVER DISEASE