Synthesis and Biological evaluation of some new 2-thioxoimidazolidin-4-one derivatives (part II)

In the present work adifferent of new heterocyclic  compounds were synthesized by reaction of thiosemicarbazide with tow aldehydes (4-bromo benzaldehyde,2-chloro benzaldehyde). the reacting `of compounds(1,2)  with ethyl chloroacetate to give 3-[(arylidene)amino]-2-sulfanyl-3,5 - dihydro-4 H -imidazol-4-one (3,4) which treating with defferent aldehydes togive chalcones  . the compound (3) reacted with ethyl aceto acetate to give ethyl 4-aryl-1-[(4-bromo benzylidene)amino]-6-oxo-2-sulfanyl-3a,4,5,6,7,7a-hexahydro-1 H -benzimidazole-5-carboxylate,and in series of reaction converted into a variety of derivatives. The prepared compounds were characterized by 1 H NMR and FTIR spectroscopy.further more antibacterial activity of some the prepared  new cyclic compounds were evaluated against three types of bacteria