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Studies evaluating the association of Interleukin 10 (IL-10) polymorphisms with risk of pediatric asthma found inconsistent data. Here, we performed a meta-analysis to get a precise estimation of the associations. Relevant studies identified in the PubMed, Scopus, CNKI databases were used to perform a meta-analysis. A total of 23 case-control studies including nine studies with 1298 cases and 1079 controls on IL-10-1082G&gt;A, four studies with 622 cases and 603 controls on -819C&gt;T and ten studies with 1480 case and 1462 controls on -592C&gt;A were selected. Overall, there was no significant association between IL-10 polymorphisms with pediatric asthma risk in global population. When stratified by ethnicity, there was a significant association of IL-10-1082G&gt;A with pediatric asthma in Asians and Chinese. This meta-analysis result revealed that IL-10-1082G&gt;A, -819C&gt;T and -592C&gt;A polymorphisms were not associated with pediatric asthma risk in the global population.

european annals of allergy and clinical immunology

Association of IL-10-1082G &gt; A, -819C &gt; T and -592C &gt; A Polymorphisms with susceptibility to asthma in children: a Systematic Review and Meta-Analysis