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Journal Compilation © 2020 Acta Dermato-Venereologica. doi: 10.2340/00015555-3355 Immune checkpoint inhibitors (ICIs) and kinase inhibitors (BRAF and MEK inhibitors) have improved clinical outcomes in patients with advanced BRAFV600 mutant melanoma. Preliminary results from ongoing, phase III clinical trials of combined ICIs and kinase inhibitors have shown a manageable safety profile with promising efficacy. However, unbridled activation of the immune system may be associated with a wide spectrum of autoimmune or inflammatory side-effects. We describe here a case of a 62-year-old woman with stage IIID melanoma, treated with anti-PD1, BRAF and MEK inhibitors, which resulted in proximal hair depigmentation of the scalp and patchy hair loss, with complete response (CR) of the disease. It can be hypothesized, that this case represents a clinical example of cross T-cell reactivity against shared antigens between tumour cells and melanocytes on previously protected sites on the hair follicle, which may indicate an anti-tumour efficacy in patients treated with ICI-based therapy.

Hair Depigmentation and Hair Loss in Advanced Melanoma Treated with Combined Immunotherapy and Targeted Therapy