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Journal Compilation © 2020 Acta Dermato-Venereologica. doi: 10.2340/00015555-3349 Rosacea is a common chronic inflammatory skin disease that almost exclusively affects the central facial skin in a symmetrical pattern. Granulomatous rosacea (GR) is the only variant of rosacea characterized by its unique histopatho logical findings (1). As with nongranulomatous rosacea (NGR), the pathogenesis of GR remains unclear. It has been shown that exposure of skin to ultraviolet radiation (UVR) upregulates matrix metalloproteinases (MMPs), mast cell, and transient receptor potential vanilloid type 1 (TRPV1) expression, and that these factors are involved in the pathogenesis of rosacea (2, 3). However, immunohistochemical expression of TRPV1 and CD117, which are key markers of neurovascular dysregulation, in GR has not been reported. This study compared the immuno histochemical expression of MMP-1, MMP-9, TRPV1 and CD117, and the grade of inflammation in GR lesions with those of NGR lesions, and attempted to identify the relationship between GR and neurovascular dysregulation.

acta dermato-venereologica

Immunohistochemical Evaluation of Matrix Metalloproteinases-1, -9, Transient Receptor Potential Vanilloid Type 1, and CD117 in Granulomatous Rosacea Compared with Non-granulomatous Rosacea