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Psoriasis is a chronic inflammatory skin disease characterized by scaly well-demarcated plaques and a high comorbidity burden. Disease management is complex and should include a patient-centred view (1). In Denmark, Dead Sea climatotherapy (DSC) has been used successfully for many years as a treatment approach to psoriasis, with excellent clearance rates (2). It is generally believed that the cutaneous symptoms of psoriasis often relapse in previously affected sites after cessation of treatment, although this has not been documented or quantified. Relapse indicates the presence of a “molecular scar” in clinically healed skin (3). The aim of this study was to determine whether recurrence of psoriasis after complete clearance occurs in a nonrandom fashion. This was determined by automated imaging in patients achieving complete clearance after treatment with DSC.

Non-random Plaque-site Recurrence of Psoriasis in Patients Treated with Dead Sea Climatotherapy