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Pegfilgrastim is a granulocyte-colony stimulating factor (G-CSF) that has recently been developed by using the pegylation technology, whereby a polyethylene glycol moiety is attached to filgrastim. Although filgrastiminduced Sweet’s syndrome has been often reported, pegfilgrastim-induced Sweet’s syndrome is rare. Here we report an additional case of neutrophilic dermatosis induced by pegfilgrastim. Moreover, we have confirmed, for the first time, the local expression of G-CSF and we discuss the pathophysiology of the lesion.

Localized Pegfilgrastim-induced Neutrophilic Dermatosis with Tissue G-CSF Expression: A Mimicker of Sweet’s Syndrome