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Verrucae vulgares are benign epidermal tumours induced by cutaneous infection with different subtypes of human papilloma virus (HPV). Spontaneous regression can occur, but treatment is usually challenging and protracted. Immunocompromised patients have a higher risk of malignant HPV-induced skin tumours and recalcitrant viral warts, which are more difficult to treat than in immunocompetent individuals. In immunocompromised patients, complications appear more frequently and severely, therefore the therapeutic regime must be chosen carefully considering possible impaired wound healing or toxicity of therapeutic agents. Therapeutic approaches can be surgical, chemical or immunomodulatory or by laser, but only limited data exist on effective treatment in immunocompromised patients.

Combination of Surgery and Nd:YAG Laser Therapy for Recalcitrant Viral Warts: A Successful Therapeutic Approach for Immunosuppressed Patients