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Psoriasis is a common, chronic, immune-mediated inflammatory disease with increased risk of cardiovascular disease and metabolic disturbances (1). The receptor for advanced glycation end products (RAGE) is a multi-ligand, pattern recognition receptor, a member of the immunoglobulin superfamily. It has the ability to engage diverse classes of ligands, including S100 proteins and advanced glycation end products. RAGE-ligand interactions have been shown to amplify and perpetuate the chronic immune-mediated inflammatory process by sustained activation of transcription factor kappa beta (NF-kappa beta). RAGE-mediated signalling triggers expression of adhesion molecules, pro-inflammatory cytokines (e.g. tumour necrosis factor alpha (TNF-alpha), interleukin (IL)-1, -6, and -8) and recruitment of inflammatory cells to the site of inflammation (2, 3). Furthermore, the activation of RAGE appears to have a central role in accelerating atherosclerosis (2, 4, 5). The potential of the RAGE-ligand axis as a target of future therapeutic intervention has been proposed (2, 4-7). The full-length form of RAGE (beta-RAGE) is a transmembrane receptor. Soluble RAGE (sRAGE) is a truncated form of RAGE, lacking the transmembrane and cytoplasmic domains. sRAGE is derived predominantly from proteolytic cleavage of beta-RAGE. sRAGE acts as an extracellular decoy receptor, antagonizing beta-RAGE by binding its ligands without mediation of any cellular activity (2-4). Therefore, it is postulated that sRAGE has protective properties in chronic inflammatory diseases and atherosclerosis (2, 3, 4, 8). Low sRAGE levels have been found in atherosclerosis, cardiovascular disease, vascular complications of diabetes and in some chronic immune-mediated disorders, such as rheumatoid arthritis. A decreased sRAGE level has been proposed as a marker for chronic inflammation and atherosclerosis (2, 3, 4, 8-10). The objective of the present study was to determine, for the first time, levels of sRAGE in individuals with chronic plaque psoriasis. The associations between sRAGE levels, severity of psoriasis, levels of C-reactive protein (CRP) and some clinical data have been evaluated.

Soluble Receptor for Advanced Glycation End Products: A Novel Biomarker for Psoriasis Severity with Therapeutic Implications?