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Primary dermal melanoma (PDM) is a rare variant of melanoma that is confined to the dermis and/or subcutaneous tissue and does not have an epidermal component (1). There are a few published case series of PDM, which suggest that patients with PDM have an excellent 5-year survival rate, ranging from 73% to 100% (1–4). PDM has a more favourable prognosis than that of primary cutaneous melanoma. More recently, several studies have revealed the molecular features of PDM (4–7). Gene mutation analyses in PDM have not found any mutations in the MAPK pathway genes (4–6). We report here a rare case of BRAFmutated, giant PDM with rapid progression. This is the first report of PDM harbouring BRAF V600E mutation.

A Case of Giant Primary Dermal Melanoma with BRAF V600E Mutation